The Department of Health and Human Services (HHS), specifically the National Institutes of Health (NIH), has announced a new funding opportunity titled "Mechanistic Investigations into ADRD Associated Protein Structures in Biological Settings" (Funding Opportunity Number PAR-24-234). This initiative aims to support research leveraging in-cell structural biology methodologies to explore the molecular and cellular mechanisms underlying Alzheimer’s disease-related dementias (ADRD). Researchers are encouraged to focus on high-resolution determination of ADRD-linked protein structures in native settings and further develop research tools to characterize structural findings. The program will provide up to $3 million annually for five years, with a cap of $500,000 direct costs per project per year. Eligible applicants include various educational institutions, nonprofits, and governmental organizations, while applications must be submitted electronically through Grants.gov by the specified deadlines. This funding aligns with the NIH's overarching goals to improve understanding of ADRD and enhance diagnostic tools and treatment strategies. Compliance with application guidelines and early submissions are emphasized to account for potential errors. Overall, this funding opportunity aims to significantly advance mechanistic understandings of ADRD through innovative structural studies.