The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at advancing the development of informatics technologies for cancer research and management. This initiative seeks applications for the enhancement of emerging informatics technologies that have shown potential in improving data acquisition, analysis, visualization, and interpretation across various aspects of cancer research, including biology, treatment, early detection, and health disparities. The emphasis is on technologies that are unique and have the potential for significant impact, with a requirement for clear development plans, user engagement, and collaboration strategies. While applications are not currently being solicited, interested parties are encouraged to prepare for submission, with the estimated synopsis post date set for August 29, 2025, and a projected award date of July 1, 2026. For further inquiries, potential applicants can contact Juli Klemm, PhD, at juli.klemm@nih.gov or by phone at 202-853-7889.