The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at soliciting applications for the early-stage development of informatics technologies that enhance cancer research and management. This initiative, part of the National Cancer Institute's Informatics Technology for Cancer Research (ITCR) Program, seeks to support the creation and significant modification of tools that facilitate data acquisition, management, analysis, and dissemination across various cancer research domains, including biology, treatment, early detection, and health disparities. Interested small businesses are encouraged to develop innovative, user-friendly technologies that demonstrate potential impact on cancer research, with applications expected to be submitted after the NOFO is officially released. For further inquiries, potential applicants can contact Dr. Juli Klemm at juli.klemm@nih.gov or by phone at 202-853-7889, with the estimated synopsis post date set for August 29, 2025, and the anticipated award date in July 2026.