The National Institutes of Health (NIH) is set to publish a Notice of Funding Opportunity (NOFO) for the Advancing Bioinformatics, Translational Bioinformatics, and Computational Biology Research initiative, which aims to support innovative research in these fields. This initiative seeks to develop advanced methods and tools that leverage transformative technologies, such as artificial intelligence and machine learning, to enhance the interpretation of complex biological datasets, ultimately improving health outcomes. With an estimated total program funding of $2.5 million and the expectation of awarding approximately 10 grants, interested small businesses are encouraged to prepare their applications, with the anticipated synopsis posting date on October 6, 2025, and a closing date for applications on February 4, 2026. For further inquiries, potential applicants can contact Dr. Catherine Farrell at catherine.farrell@nih.gov or by phone at 301-402-7081.