The National Institutes of Health (NIH) is announcing a forthcoming opportunity for research grants in Clinical Informatics, specifically under the R01 Clinical Trial Optional funding mechanism. This initiative aims to support innovative research that develops and evaluates clinical informatics tools and methodologies, enhancing the ability of clinicians and patients to manage health care delivery effectively. The program emphasizes the creation of scalable and reusable approaches to transform diverse health data into actionable insights, ultimately improving clinical workflows and health outcomes. With an estimated total funding of $2.5 million and the expectation of awarding approximately 10 grants, interested applicants are encouraged to prepare their proposals ahead of the anticipated application period, which is expected to open following the synopsis posting on October 6, 2025. For further inquiries, potential applicants can contact Goutham Reddy at goutham.reddy@nih.gov or by phone at 301-827-6728.