The National Institutes of Health (NIH) is offering a funding opportunity titled "Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research" through Cooperative Agreements (U01). This initiative aims to advance research in cancer etiology and early detection biomarkers by utilizing the unique biorepository resources from the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial, which includes pre-diagnostic blood samples and associated clinical data. The research projects must specifically involve PLCO biospecimens and focus on exploring cancer risk factors and early detection biomarkers, with the overarching goal of reducing cancer risk and improving the quality of life for survivors. Interested applicants can find more information and submit their proposals by the closing date of October 8, 2027, and should direct inquiries to grantsinfo@nih.gov for further assistance.