Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed)
ID: 356718Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/356718

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-074.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Assay Validation of High Quality Markers for Clinical Studies in Cancer" through a cooperative agreement mechanism (UH2/UH3). This initiative aims to support the validation of molecular, cellular, and imaging biomarkers essential for cancer detection, diagnosis, prognosis, and treatment response monitoring, with a focus on both analytical and clinical validation phases. The funding is intended for projects that demonstrate a working assay on human samples and justify its clinical relevance, fostering multi-disciplinary collaborations among scientific investigators, oncologists, and clinical laboratory scientists. Interested applicants should note that the application deadline is October 14, 2026, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries. More details can be found at the provided link: https://grants.nih.gov/grants/guide/pa-files/PAR-25-074.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-074.html
    The National Cancer Institute (NCI) of the Department of Health and Human Services is issuing a funding opportunity for the assay validation of high-quality biomarkers for cancer clinical studies. This initiative invites applications through a cooperative agreement mechanism (UH2/UH3) where projects focus on the analytical and clinical validation of molecular, cellular, and imaging markers crucial for cancer detection, diagnosis, and treatment response monitoring. The funding supports both phases: the UH2 phase for analytical validation, which lasts up to two years, and the UH3 phase for clinical validation spanning three years. Collaborations among investigators from diverse fields are essential to ensure successful assay integration into cancer trials. Key eligibility criteria include a proven working assay with human samples and the ability to justify its clinical relevance. Applications must propose specific milestones for transitioning between the UH2 and UH3 phases. The initiative aims to overcome regulatory challenges and support the refinement of assays needed for effective cancer treatment, prevention, and control studies, with the ultimate goal of making established assays accessible for clinical application in the healthcare community.
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