The National Institutes of Health (NIH) is offering a funding opportunity titled "Transgender People: Immunity, Prevention, and Treatment of HIV and STIs (R21 Clinical Trial Not Allowed)" aimed at supporting exploratory research into the biological and immunological effects of gender reassignment interventions on HIV and STI susceptibility among transgender individuals. This initiative seeks to address the significant health disparities faced by transgender populations, who are at a notably higher risk of HIV infection, by investigating the physiological changes resulting from gender-affirming therapies. Eligible applicants include a wide range of organizations, with a total funding ceiling of $275,000 available over a two-year period, and applications must be submitted by December 7, 2024. For further details, interested parties can contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov or visit the additional information link at http://grants.nih.gov/grants/guide/pa-files/PAR-22-186.html.