The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) titled "Addressing Health and Health Care Disparities among Sexual and Gender Minority Populations (R01 - Clinical Trials Optional)." This initiative aims to support innovative observational and intervention-based research that investigates the pathways and mechanisms contributing to health disparities among sexual and gender minority populations, particularly those from underrepresented racial/ethnic and socio-economic backgrounds. The research is expected to focus on social determinants of health, minority stress influences, and health outcomes related to chronic conditions such as cardiovascular disease and mental health disorders. Eligible applicants can request funding for direct costs up to $500,000 annually for projects lasting up to five years, with the application submission window opening on January 5, 2024. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information page at https://grants.nih.gov/grants/guide/pa-files/PAR-24-077.html.