The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) aimed at addressing health disparities among sexual and gender minority populations. This funding initiative will support observational and intervention-based research that explores the mechanisms causing these disparities, focusing particularly on underrepresented racial/ethnic and socio-economic groups. Key areas of interest include examining the social determinants of health, minority stress influences, and health outcomes linked to chronic conditions like cardiovascular disease and mental health disorders. Applications are encouraged to use multidisciplinary approaches and involve community participation to ensure relevancy and effectiveness in addressing the identified health challenges. Researchers can request funding for direct costs up to $500,000 annually for projects with a maximum duration of five years. Eligible applicants include various educational and healthcare institutions, nonprofits, and governmental bodies, with the submission window opening on January 5, 2024. The overarching goal is to foster innovative research that translates findings into effective interventions to reduce health inequities within sexual and gender minority populations.