GrantPostedDiscretionary

Aging Mammalian Tissues In Vitro (R21 Clinical Trial Not Allowed)

National Institutes of Health
RFA-AG-26-014
Application Deadline
Oct 20, 2025
Closed
Days Remaining
0
Deadline passed
Award Ceiling
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) is inviting applications for the "Aging Mammalian Tissues In Vitro (R21 Clinical Trial Not Allowed)" funding opportunity, aimed at advancing interdisciplinary research in developing complex 3D in vitro microphysiological systems (MPS) that model aging processes observed in vivo. The initiative primarily focuses on human cell-derived MPS, encouraging innovative approaches from various fields such as aging biology, stem cell biology, and bioengineering, with the goal of enhancing the adoption of MPS in aging biology research and drug discovery. NIH plans to allocate $2.4 million in FY 2026 for approximately 10 awards, with each project budget capped at $275,000 in direct costs over two years. Interested applicants can find more details and submit inquiries via grantsinfo@nih.gov, with applications due by October 20, 2025.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grant Documents

2 Files
RFA-AG-26-014-Full-Announcement.html
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RFA-AG-26-014.html
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AI Summary
The Department of Health and Human Services, National Institute on Aging (NIA), is inviting applications for the "Aging Mammalian Tissues In Vitro (R21 Clinical Trial Not Allowed)" funding opportunity. This initiative seeks interdisciplinary research to develop complex mammalian 3D in vitro microphysiological systems (MPS) that model aging processes observed in vivo, primarily focusing on human cell-derived MPS. The R21 activity code supports exploratory research, not requiring preliminary data, and emphasizes multidisciplinary approaches from fields like aging biology, stem cell biology, bioengineering, and computational biology. The goal is to advance MPS adoption in aging biology research and drug discovery. NIA intends to commit $2.4 million in FY 2026 for approximately 10 awards, with budgets limited to $275,000 in direct costs over two years. Eligible applicants include various higher education institutions, nonprofits, and for-profit organizations, with foreign organizations generally excluded. Applications must define the 3D in vitro system, explain the approach to attaining aging phenotypes, specify measurable aging phenotypes, and benchmark the MPS against known in vivo human aging parameters or relevant animal models. The review process will prioritize the importance of research, rigor, feasibility, expertise, and resources, with an emphasis on innovation and the potential for significant impact.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedAug 26, 2025
deadlineApplication DeadlineOct 20, 2025
expiryArchive DateNov 25, 2025

Funding Details

No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Grant

Grantor Contact

CFDA Numbers

93.866

Official Sources