The National Institutes of Health (NIH) is inviting applications for the Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) grant, aimed at supporting large-scale, multidisciplinary research projects focused on aging. This opportunity encourages the formation of collaborative teams that will propose integrated research programs addressing a common hypothesis related to aging, with an emphasis on coordination among various project components. While applications are not currently being solicited, potential applicants are encouraged to prepare meaningful collaborations and responsive projects in anticipation of the upcoming Notice of Funding Opportunity (NOFO), with an estimated synopsis posting date of March 25, 2026, and a closing date of May 25, 2026. For further inquiries, interested parties can contact the NIA Scientific Contact at nia_scicontact@mail.nih.gov.