The USAID/Southern Africa has issued a Request for Information (RFI) regarding a potential funding opportunity aimed at addressing the HIV epidemic among children, adolescents, and families in Limpopo Province, South Africa. The anticipated funding of up to $25 million, designated for local entities, seeks to enhance health and social service systems, aiming to achieve the 95-95-95 goals by 2025. The program's focus includes increasing access to comprehensive health services, particularly for vulnerable populations, and fortifying local governance and capacity within service agencies. Interested organizations are invited to provide feedback on the draft Notice of Funding Opportunity (NOFO) attached to the RFI, emphasizing areas needing clarification or improvement. The feedback will inform the final proposal but is not considered a funding application. All submissions must follow specified formatting and be emailed by the deadline of May 29, 2023. The program recognizes the critical intersection of economic, educational, and health challenges faced by children and adolescents affected by HIV, particularly in Limpopo, where poverty rates are high. It aims to implement evidence-based interventions that strengthen local response systems and improve long-term health outcomes for the province's youth.