The United States Agency for International Development (USAID) is seeking input for the South Africa Health Financing Activity, a prospective five-year initiative aimed at enhancing health financing mechanisms in South Africa. This Request for Information (RFI) invites interested parties to provide evidence-based suggestions on challenges related to domestic resource mobilization for health, human resources for health, and targeted financing interventions, particularly in the context of HIV/AIDS, TB, and COVID-19 responses. The insights gathered will be utilized to improve fiscal efficiency and address public health challenges within the South African health system. Interested organizations, especially local entities, are encouraged to submit their responses by September 2, 2022, and can direct inquiries to Boitumelo P Mahlomoje at bmahlomoje@usaid.gov or by phone at 0124522000.