The United States Agency for International Development (USAID) Mission to Southern Africa is inviting applications for a five-year cooperative agreement aimed at implementing comprehensive district-based HIV-related services to improve patient outcomes. This initiative seeks organizations capable of delivering effective support programs, as detailed in the Request for Applications (RFA). The funding opportunity, categorized under health, has an estimated total program funding of $75 million, with individual awards ranging from $1 to $20 million, and is expected to result in four awards. Interested applicants are encouraged to participate in a pre-application conference on May 14, 2012, in Johannesburg, South Africa, to clarify the RFA’s objectives and application procedures; registration is required by emailing Lulama Makena and Zweli Zindela by January 23, 2012. For further inquiries, applicants can contact Beatrice Lumande at Applications4@usaid.gov or by phone at +27 12 452 2377.