The National Institutes of Health (NIH) solicits applications for pilot studies examining biological, behavioral, and social mechanisms contributing to HIV pathogenesis under the auspices of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This funding opportunity, titled "Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK," invites exploratory and developmental research aligned with NIH HIV/AIDS priorities. The objective is to investigate comorbidities linked to HIV and their underlying mechanisms, particularly in connection with the gastrointestinal tract, kidney, and metabolic diseases. Researchers may propose projects involving human subjects, animal models, or observational studies but not clinical trials. Grant applications must comply with NIH policies, and the funding is capped at $275,000 over two years, with potential funding dependent on the merit of applications received. Eligible applicants include higher education institutions, nonprofits, and various government entities. Key deadlines for submission begin in April 2025, with deadlines for subsequent applications extending into 2028. Overall, this initiative aims to enhance understanding of the complex interplay between HIV, associated diseases, and social determinants of health to inform effective prevention and treatment strategies.