The National Institutes of Health (NIH) has announced a funding opportunity for epidemiologic research on emerging risk factors associated with liver cancer in the United States, specifically through the R21 Clinical Trial Not Allowed mechanism. This initiative aims to explore innovative hypotheses regarding biological, environmental, and social risk factors, while excluding applications focused solely on viral hepatitis as the etiologic factor. The research is crucial for informing prevention strategies and addressing the rising rates of liver cancer, particularly hepatocellular carcinoma, among various U.S. populations. Interested applicants can apply for a budget of up to $275,000 over two years, with the application process opening on January 16, 2025, and the submission deadline set for May 7, 2025. For further inquiries, applicants may contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PA-25-123.html.