The National Institutes of Health (NIH) has issued a Notice of Funding Opportunity (NOFO) aimed at promoting secondary analysis and integration of existing data to understand cancer risks and outcomes. Specifically, the National Cancer Institute (NCI) seeks applications that utilize datasets such as clinical, environmental, and genomic data to tackle scientific questions related to cancer. The funding opportunity, outlined under the R21 Exploratory/Developmental Research Grant, allows for a project duration of two years with a maximum budget of $275,000, emphasizing innovative and cost-effective research approaches. Key objectives include identifying cancer risks and exploring preventive strategies, leveraging existing data through advanced analytical methods, and addressing significant research questions in cancer control and population sciences. Eligible applicants range from higher education institutions to nonprofit organizations and state governments. The NOFO also outlines specific requirements for application submission, evaluation criteria, and expectations for data sharing post-research. The funding initiative reflects NIH’s commitment to enhancing cancer research by maximizing the utility of current data resources while strictly prohibiting clinical trials in the applications submitted.