The Department of Health and Human Services (HHS), through its National Institutes of Health (NIH), is offering funding opportunities aimed at reducing disparities in liver diseases and liver cancer in the U.S. The initiative supports multi-level intervention research targeting racial and ethnic minority populations, individuals with low socioeconomic status, and sexual and gender minorities. Applications are encouraged to improve prevention, screening, treatment, and management of liver conditions and to engage communities meaningfully. Key considerations include: projects must address social determinants of health (SDOH) affecting health outcomes, utilize interdisciplinary approaches, and include measures for biological, behavioral, and socio-cultural domains. The application deadline is set for February 2024, with awards contingent upon meritorious applications. Applicants must follow stringent submission guidelines and are encouraged to propose culturally sensitive interventions, assess multi-level impacts, and consider diverse populations. The overall goal is to advance health equity and improve quality of care among underserved communities affected by liver disease and liver cancer.