The Department of Health and Human Services, in collaboration with various National Institutes of Health (NIH) components, issues a Notice of Funding Opportunity (NOFO) for research to enhance the adoption and implementation of evidence-based health interventions. This initiative aims to overcome barriers in public health by promoting equitable dissemination, particularly in underrepresented communities, and understanding when to discontinue ineffective practices. The program is open for applications specifically under the R01 Research Project Grant activity code, and encourages multidisciplinary collaboration to improve community health outcomes. Key funding priorities include advancing health equity, integrating diverse stakeholder perspectives, and enhancing the sustainability of health interventions. Applications require a focused Plan for Enhancing Diverse Perspectives (PEDP) and must adhere to specific guidelines about research methodologies and study designs. Funding availability depends on NIH appropriations, and the maximum project period for grants is five years. The NOFO explicitly supports studies that address social determinants of health, community engagement, and diverse methods of implementation research. Interested parties are advised to consult with relevant NIH contacts to align proposals with specific institute missions and priorities.