The Department of Health and Human Services' funding opportunity announcement (FOA) outlines a program for the establishment of Biomedical Technology Optimization and Dissemination (BTOD) Centers, aimed at enhancing late-stage technologies essential for biomedical research. This FOA encourages applications from various eligible institutions, including higher education and nonprofit organizations. Successful applicants will focus on optimizing technologies proven effective in lab settings and disseminating these improvements to the broader research community to facilitate independent use. Key features of the BTOD Centers include collaborative technology optimization (TOP) projects, driving biomedical projects (DBPs), and community engagement strategies aimed at training users and promoting widespread adoption of the technologies developed. Each center is expected to have a maximum funding period of 15 years and must demonstrate diversity and inclusivity through a Plan for Enhancing Diverse Perspectives. The FOA emphasizes adherence to application guidelines and submission requirements, including assurances of compliance with data management and sharing policies. Ultimately, the program seeks to create self-sustaining technologies that meet the needs of a broad spectrum of biomedical researchers while fostering innovation and broad accessibility to optimized tools. This initiative reflects the NIH's commitment to advancing scientific research through collaborative and inclusive approaches.