BRAIN Initiative: Engineering and optimization of molecular technologies for functional dissection of neural circuits (UM1 Clinical Trial Not Allowed)
ID: 343315Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
    Description

    The National Institutes of Health (NIH) has announced a funding opportunity for the BRAIN Initiative, focusing on the engineering and optimization of molecular technologies for the functional dissection of neural circuits. This initiative aims to develop high-impact molecular tools that can monitor and manipulate neural cell activity, facilitating advancements in neuroscience research and the treatment of brain disorders. The funding, estimated at $13 million annually, will support 5 to 9 awards over a maximum project period of five years, with applications due by October 17, 2024. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov or visit the official announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-245.html.

    Point(s) of Contact
    Files
    Title
    Posted
    The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a funding opportunity announcement (FOA) for the BRAIN Initiative aimed at optimizing molecular technologies for monitoring and manipulating brain cell activity. This initiative focuses on creating Molecular Payloads Centers dedicated to developing high-impact molecular probes and tools necessary for neuroscience research, ultimately enhancing the understanding and treatment of brain disorders. Key components of this FOA include research objectives that promote collaboration among diverse scientific teams, emphasizing the significance of inclusion in advancing neuroscientific research. Applicants are required to adhere to specific application processes, including the submission of a Plan for Enhancing Diverse Perspectives and a Proposed Milestones and Timeline. Funding is estimated at $13 million annually, with 5 to 9 awards available over a maximum project period of five years. The FOA highlights the importance of close interaction among technology developers and neurobiologists to validate improvements and adapt tools for broad use. The NIH aims to ensure that optimized molecular tools become widely accessible, thus facilitating transformative advances in the field of neuroscience.
    Similar Opportunities
    BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity under the BRAIN Initiative, aimed at developing and validating novel tools to analyze cell-specific and circuit-specific processes in the brain. This initiative seeks proposals that focus on creating innovative technologies to enhance the understanding of complex neural behaviors and interactions, particularly tools that are non-invasive and applicable across various model organisms. The program is critical for advancing research in brain function and disorders, with an estimated funding total of $8 million to support 6-9 awards, and applications are due by May 7, 2024. Interested applicants must submit a Plan for Enhancing Diverse Perspectives (PEDP) and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting applications for the BRAIN Initiative, specifically targeting the optimization of instrumentation and device technologies for recording and modulation in the nervous system. This funding opportunity aims to enhance the understanding of neural circuits by supporting projects that utilize innovative technologies, such as optical, electrical, magnetic, or acoustic methodologies, to address significant challenges in neuroscience research. Successful proposals should demonstrate a commitment to interdisciplinary collaboration and include a Plan for Enhancing Diverse Perspectives (PEDP) to foster inclusivity among diverse teams and institutions. The initiative anticipates awarding approximately $10 million across 15-20 projects, with applications due by January 20, 2026. For further details, interested applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the official announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-017.html.
    BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System," aimed at enhancing technologies for recording neural activity and addressing significant challenges in neuroscience research. This initiative seeks applications focused on optimizing existing or emerging technologies through iterative testing with end users, with the goal of improving network recording capabilities and developing tools for circuit manipulation that can be validated in vivo. The funding, anticipated at $10 million per year for 15-20 awards, requires applicants to include a Plan for Enhancing Diverse Perspectives (PEDP) to promote inclusivity in research, with submissions due by January 20, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative, titled "New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)." This initiative aims to support proof-of-concept testing and the development of innovative neurotechnologies that can enhance the understanding of brain circuit dynamics and facilitate transformative neuroscience research. The program encourages high-risk, high-impact projects that integrate diverse scientific domains and require applicants to submit a Plan for Enhancing Diverse Perspectives (PEDP) as part of their proposals. The total estimated funding available is $10 million annually, with plans to support 15-20 awards over a maximum project period of three years. Interested applicants must adhere to strict submission guidelines, and the application deadline is January 20, 2026. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative for research on the ethical implications of advancements in neurotechnology and brain science, designated as R21 Clinical Trial Optional grants. This initiative invites multi-disciplinary teams to explore critical ethical issues related to brain research, including topics such as brain imaging, data privacy, and informed consent, with the aim of fostering diverse collaborations and addressing significant ethical challenges in the field. The total funding available is $2 million annually over three years, supporting up to eight new awards, with individual project budgets capped at $275,000 for a two-year period. Interested applicants should note that the application period opens on September 11, 2024, and closes on October 9, 2026; for further inquiries, they can contact NIH Grants Information at grantsinfo@nih.gov.
    BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative to support the development of innovative recording and modulation technologies for diagnosing and treating central nervous system (CNS) diseases. The initiative aims to advance technologies from proof of concept to readiness for first-in-human studies, encouraging diverse, team-based applications that integrate various domains of expertise. This funding opportunity, with an award ceiling of $750,000 and a total budget of approximately $8 million for 5-7 awards, requires applicants to submit a Plan for Enhancing Diverse Perspectives and several key attachments. Interested parties should note that the application submission period begins on April 29, 2024, and closes on January 28, 2027. For further details, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-031.html.
    BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative for exploratory research using invasive neural recording and stimulating technologies in the human brain. This initiative aims to assemble diverse, multidisciplinary teams to investigate high-impact questions in human neuroscience, focusing on establishing feasibility and proof-of-principle for future invasive studies while addressing clinical and ethical considerations. The NIH plans to commit approximately $6 million to fund multiple awards, with each application budget capped at $700,000 for direct costs per year over a maximum project period of three years. Interested applicants can find more information and submit inquiries via email at grantsinfo@nih.gov, with the application deadline set for September 19, 2025.
    BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative to support clinical studies aimed at advancing next-generation devices for recording and modulation within the human central nervous system (CNS). This initiative encourages proposals for early-stage clinical investigations, including first-in-human studies, that focus on treating CNS disorders and enhancing understanding of brain functions, particularly through Significant Risk studies requiring FDA Investigational Device Exemptions (IDEs) for chronic implants. The NIH plans to allocate approximately $10 million annually to fund 5 to 7 projects, emphasizing the importance of collaborations with device manufacturers through a public-private partnership program, and requires a Plan for Enhancing Diverse Perspectives as part of the application. Interested applicants can find more information and submit inquiries via grantsinfo@nih.gov, with the application deadline set for January 28, 2027.
    BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative for the development of next-generation sensor technologies and bioelectronic devices, specifically through the Brain Behavior Quantification and Synchronization (BBQS) program. This initiative aims to enhance the measurement of simultaneous behavior and neural activity in various environments, encouraging interdisciplinary collaborations among engineers and behavioral scientists to create compact, reliable sensors that integrate with brain recording data. The NIH plans to allocate approximately $10 million to fund 6-8 awards, with each project lasting up to five years, and requires applicants to submit a Plan for Enhancing Diverse Perspectives to promote inclusivity in research teams. Interested parties can find more information and apply by visiting the official announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-26-140.html, with applications due by June 15, 2027.
    BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative to support the development of next-generation devices for recording and modulation in the human central nervous system. This initiative aims to facilitate translational activities and small clinical studies focused on therapeutic and diagnostic devices for CNS disorders, particularly those requiring Investigational Device Exemptions (IDE) for significant risk studies. The program emphasizes milestone-driven cooperative agreements, collaboration among diverse research teams, and the inclusion of a Plan for Enhancing Diverse Perspectives (PEDP) to promote equitable access in research. With an annual budget of $10 million available for approximately 5 to 7 awards, interested applicants can find more information and apply starting April 29, 2024, by contacting NIH Grants Information at grantsinfo@nih.gov.