Scheduled maintenance until 6:00 AM EST.
BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)
ID: 346912Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
  1. 1
    Forecast Posted Not available
  2. 2
    Forecast Due Not available
  3. 3
    Posted Mar 14, 2023 12:00 AM
  4. 4
    Due Jan 20, 2026 12:00 AM
Description

The National Institutes of Health (NIH) is offering a grant opportunity titled "BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)". This grant aims to support the development and testing of innovative technologies and approaches for recording and modulation of cells and networks in the central nervous system (CNS). The goal is to gain a transformative understanding of dynamic signaling in the CNS at various spatial and temporal scales. The proposed technologies should be compatible with experiments in behaving animals and capable of reducing barriers to conducting neurobiological experiments. The grant encourages the integration of multiple approaches and expertise from biological, chemical, physical sciences, engineering, computational modeling, and statistical analysis. The deadline for application submission is January 20, 2026. For more information and to apply, visit the following link: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-004.html.

Point(s) of Contact
Files
Title
Posted
Similar Opportunities
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
National Institutes of Health
The National Institutes of Health is offering a grant opportunity titled "BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)". This grant aims to support activities that facilitate the translation of novel recording and modulation technologies for the treatment and diagnosis of central nervous system (CNS) diseases and disorders. The technologies may utilize various signal modalities such as electrical, optical, magnetic, or acoustic, either individually or in combination. The grant encourages diverse team-based applications that integrate different areas of expertise. The deadline for application submission is January 28, 2027. For more information and to apply, visit the following link: [http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-031.html](http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-031.html).
BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)
National Institutes of Health
The National Institutes of Health (NIH) has posted a grant opportunity titled "BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)". This grant aims to support the development of unique and innovative recording and/or modulation technologies in the early stages of development. The goal is to enhance the capabilities of recording or modulation in the nervous system, including improving precision, selectivity, and scalability. The grant encourages applications from qualified individuals in various fields such as chemistry, physics, engineering, and materials science, who may not typically be involved in neuroscience research. The technologies can be invasive or non-invasive and should be compatible with experiments in humans or behaving animals. The grant requires a Plan for Enhancing Diverse Perspectives (PEDP) as part of the evaluation process. The deadline for applications is June 15, 2026. For more information and to apply, visit the following link: [http://grants.nih.gov/grants/guide/rfa-files/RFA-EY-23-001.html](http://grants.nih.gov/grants/guide/rfa-files/RFA-EY-23-001.html).
BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)
National Institutes of Health
The National Institutes of Health is offering a federal grant opportunity titled "BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)". This grant aims to optimize existing or emerging technologies for recording and modulation in the nervous system. The technologies and approaches should have the potential to address major challenges associated with recording and modulation of cells and networks in the central nervous system (CNS). The goal is to enable a transformative understanding of dynamic signaling in the CNS. The proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing barriers to conducting neurobiological experiments. The grant encourages the integration of multiple approaches and expertise from various domains such as biological, chemical, physical sciences, engineering, computational modeling, and statistical analysis. For more information and to apply, visit the following link: [http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-005.html](http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-005.html).
BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)
National Institutes of Health
The National Institutes of Health is offering a grant opportunity titled "BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)". This grant aims to support research projects that utilize invasive surgical procedures to record and stimulate intracranially within specific brain structures in humans. The goal is to address research questions in human neuroscience by assembling diverse, integrated, multi-disciplinary teams that can overcome the limitations of limited resources and patient availability. The research should focus on feasibility, proof-of-principle, and early-stage development to lay the groundwork for potential future research opportunities. Projects should maximize the opportunities provided by direct access to the brain through invasive surgical procedures and employ approaches guided by theoretical constructs and quantitative, mechanistic models. Awardees will join a consortium working group coordinated by the NIH to establish consensus standards of practice, collect and provide data for ancillary studies, and disseminate aggregated and standardized data to the scientific community. The grant does not require cost sharing or matching and is open to various eligible applicants. The deadline for application submission is September 19, 2025. For more information, please visit the [grant opportunity website](http://grants.nih.gov/grants/guide/rfa-files/RFA-DC-24-001.html).
BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)
National Institutes of Health
The National Institutes of Health (NIH) has posted a grant opportunity titled "BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)". This grant aims to support the development of therapeutic and diagnostic devices for disorders affecting the nervous or neuromuscular systems. The program will fund translational activities and small clinical studies, including the implementation of clinical prototype devices, safety and efficacy testing, design verification and validation activities, and obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study. The grant is a cooperative agreement program and will involve NIH program staff in negotiating the final project plan and monitoring research progress. Eligible applicants include various institutions and organizations, such as Alaska Native and Native Hawaiian Serving Institutions, Faith-based or Community-based Organizations, and U.S. Territories or Possessions. The deadline for applications is January 28, 2027. For more information and to apply, visit the following link: [http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-016.html](http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-016.html). For any inquiries, contact NIH Grants Information at grantsinfo@nih.gov.