The South Africa USAID-Pretoria is offering a federal grant opportunity titled "HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS North." This initiative aims to significantly reduce HIV incidence among adolescent girls and young women (AGYW) aged 10-24 in high-prevalence areas of South Africa, specifically targeting the provinces of Mpumalanga, Gauteng, and Limpopo. The program focuses on enhancing access to comprehensive, evidence-based prevention interventions while addressing the socio-economic determinants of HIV risk, including gender-based violence and health service utilization. Eligible local entities are invited to submit concept papers by February 11, 2025, with an anticipated funding range of $52 million to $58 million over five years, and a 10% cost-sharing requirement is mandated for applicants. For further inquiries, interested parties can contact Alejandra Garcia at pretoriaapplications@usaid.gov.