The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for strategies to prevent cardiovascular disease in young adults with high lifetime risk using surrogate outcomes. This funding opportunity aims to support a multisite clinical trial that will test a screening approach to identify coronary atherosclerosis and interventions to reduce its progression. The trial will require a cooperative agreement and will include a Clinical Coordinating Center (CCC) and a collaborating Data Coordinating Center (DCC) application. The CCC and DCC applications must be submitted together for consideration. The anticipated publication date for the funding opportunity is Summer 2024, with an expected application due date in Fall 2024. The estimated award date and project start date are both August 1, 2025.