Phased Multi-Site Clinical Trial: Testing Prevention of Cardiovascular Disease in Young Adults With High Lifetime Risk Using Surrogate Outcomes - Clinical Coordinating Center (Collaborative UG3/UH3 Clinical Trial Required)
ID: 355312Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/355312

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-25-010.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity for a Phased Multi-Site Clinical Trial aimed at preventing cardiovascular disease in young adults with high lifetime risk, through the establishment of a Clinical Coordinating Center (CCC). The trial seeks to identify young adults with subclinical coronary atherosclerosis and evaluate interventions to slow its progression, utilizing a two-phase cooperative agreement structure (UG3/UH3). This initiative is crucial for improving cardiovascular health outcomes in young populations and emphasizes the importance of innovative trial designs, community engagement, and diverse participant recruitment. Interested applicants must submit their proposals by October 28, 2024, and can find further details and contact information at grantsinfo@nih.gov or through the announcement link at https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-25-010.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-HL-25-010-Full-Announcement.html
    RFA-HL-25-010.html
    The Department of Health and Human Services, through the National Heart, Lung, and Blood Institute (NHLBI), has announced a funding opportunity for a multi-site clinical trial aimed at preventing cardiovascular disease in young adults at high lifetime risk. The trial, titled "Phased Multi-Site Clinical Trial: Testing Prevention of Cardiovascular Disease in Young Adults With High Lifetime Risk Using Surrogate Outcomes," will utilize a two-phase cooperative agreement structure (UG3/UH3). The primary goals are to identify young adults with subclinical coronary atherosclerosis and assess interventions to slow its progression. Applicants must develop a Clinical Coordinating Center (CCC) plan, which should incorporate innovative trial designs, project management, and strategies for recruiting diverse participants. A companion Data Coordinating Center application is also required for consideration. Key aspects include establishing performance milestones, incorporating community engagement, and enhancing diverse perspectives. The funding opportunity emphasizes a strong scientific rationale and operational plans, with specific budget allocations outlined for fiscal years 2025 through 2031. Eligible applicants include higher education institutions, nonprofits, for-profits, and government entities, particularly those fostering inclusivity and diverse perspectives in research. Overall, this initiative aims to improve cardiovascular health outcomes in young populations through rigorous scientific evaluation and community involvement.
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