Immunobiology of Xenotransplantation (U19 Clinical Trial Not Allowed)
ID: 353310Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/353310

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-020.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting applications for the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP), aimed at addressing immunologic and physiological challenges in xenotransplantation. Applicants are required to propose at least two synergistic research projects that outline strategies to overcome barriers affecting the survival and function of xenografts, with a focus on preclinical studies involving organ transplants from genetically modified pigs to nonhuman primates or human decedents. This initiative is critical in the context of increasing organ transplant demands, as it seeks to mitigate risks such as immune rejection and zoonotic disease transmission. A total funding of $6.4 million is available for three to five cooperative agreement awards, with a maximum project duration of five years. Interested parties can find more information and submit inquiries via grantsinfo@nih.gov, and the application deadline is August 9, 2024.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-AI-24-020-Full-Announcement.html
    RFA-AI-24-020.html
    The National Institutes of Health's (NIH) funding opportunity, RFA-AI-24-020, seeks applications for the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP). This program aims to advance research on overcoming immunologic and physiological challenges in xenotransplantation, specifically using preclinical models for organ transplants from genetically modified pigs to nonhuman primate or human decedent recipients. With the increasing demand for organ transplants, the IXCRP offers a potential solution through xenotransplantation, while addressing significant risks such as immune rejection and zoonotic disease transmission. Applications must include at least two synergistic research projects and demonstrate a clear strategy for addressing barriers impacting the survival and function of xenografts, along with explicit annual milestones for progress evaluation. Funding totaling $6.4 million is available for three to five cooperative agreement awards, with a maximum project period of five years. Only preclinical studies are allowed under this opportunity, excluding clinical trials. Eligible organizations include various educational institutions and governmental bodies, emphasizing diverse participation in this critical area of biomedical research.
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