Immunobiology of Xenotransplantation (U19 Clinical Trial Not Allowed)
ID: 353310Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/353310

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-020.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting applications for the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP), aimed at addressing immunologic and physiological challenges in xenotransplantation. Applicants are required to propose at least two synergistic research projects that outline strategies to overcome barriers affecting the survival and function of xenografts, with a focus on preclinical studies involving organ transplants from genetically modified pigs to nonhuman primates or human decedents. This initiative is critical in the context of increasing organ transplant demands, as it seeks to mitigate risks such as immune rejection and zoonotic disease transmission. A total funding of $6.4 million is available for three to five cooperative agreement awards, with a maximum project duration of five years. Interested parties can find more information and submit inquiries via grantsinfo@nih.gov, and the application deadline is August 9, 2024.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-AI-24-020-Full-Announcement.html
    RFA-AI-24-020.html
    The National Institutes of Health's (NIH) funding opportunity, RFA-AI-24-020, seeks applications for the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP). This program aims to advance research on overcoming immunologic and physiological challenges in xenotransplantation, specifically using preclinical models for organ transplants from genetically modified pigs to nonhuman primate or human decedent recipients. With the increasing demand for organ transplants, the IXCRP offers a potential solution through xenotransplantation, while addressing significant risks such as immune rejection and zoonotic disease transmission. Applications must include at least two synergistic research projects and demonstrate a clear strategy for addressing barriers impacting the survival and function of xenografts, along with explicit annual milestones for progress evaluation. Funding totaling $6.4 million is available for three to five cooperative agreement awards, with a maximum project period of five years. Only preclinical studies are allowed under this opportunity, excluding clinical trials. Eligible organizations include various educational institutions and governmental bodies, emphasizing diverse participation in this critical area of biomedical research.
    Similar Opportunities
    Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting research project applications for the grant opportunity titled "Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research." This initiative aims to support hypothesis-driven projects that develop technologies and resources to improve the validity and applicability of animal research across multiple organ systems and diseases, addressing critical gaps identified in previous workshops. The funding is crucial for enhancing research methodologies in biomedical applications, with awards available for up to five years and a maximum budget of $500,000, requiring pre-approval for requests exceeding this amount. Interested applicants can find more information and application guidelines at the NIH Grants Information website or contact grantsinfo@nih.gov, with the application deadline set for September 7, 2025.
    Limited Competition: National Primate Research Centers (P51) (Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity for the Limited Competition: National Primate Research Centers (P51), aimed at supporting basic and translational research utilizing nonhuman primates (NHPs). This grant is specifically designed for existing National Primate Research Centers (NPRCs) to provide essential resources, expertise, and animal models crucial for advancing understanding of human biology in both normal and diseased states. The NPRCs play a vital role in biomedical research by ensuring rigorous study designs, facilitating pilot research projects, and promoting ethical treatment of research animals. Interested applicants must submit their proposals by January 25, 2024, with a maximum project period of five years, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries. More details can be found in the full announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-23-126.html.
    Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models," aimed at supporting preclinical research on HIV/AIDS conducted by early-stage investigators with at least two years of postdoctoral experience. This funding initiative encourages innovative research approaches utilizing NHP models to develop next-generation therapies and strategies for HIV cure, aligning with the NIH Strategic Plan priorities for HIV research. Eligible applicants can request up to $200,000 in direct costs annually, with a total budget cap of $400,000 over two years, and must adhere to specific application procedures. The application deadline is September 7, 2025, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)." This initiative invites applications aimed at improving the utility of mammalian cancer models, including organoids and tumoroids, to better represent human biology and address translational deficiencies in existing models. The funding seeks to advance cancer research by fostering innovative approaches to validate these models and enhance their clinical relevance, ultimately aiming to improve patient outcomes. Eligible applicants can receive up to $499,000 per year for a maximum of five years, with applications due by September 7, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-281.html.
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)," aimed at improving the utility of mammalian cancer models in translational research. This initiative seeks projects that enhance the accuracy and application of models, such as organoids and tumoroids, to better represent human biology and inform clinical practices, addressing current limitations and fostering innovation in cancer research methodologies. Eligible applicants include a diverse range of organizations, such as higher education institutions and community-based organizations, with a maximum funding amount of $499,000 per year for projects not exceeding five years. Interested parties should submit their applications through Grants.gov, with deadlines beginning January 5, 2025, and can direct inquiries to grantsinfo@nih.gov for further information.
    Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed)" aimed at supporting Early Stage Investigators (ESIs) in conducting innovative preclinical research on HIV/AIDS using NHP models. This grant initiative seeks to empower researchers who are within ten years of their terminal degree and have at least two years of postdoctoral experience, enabling them to explore new research directions that align with the NIH Strategic Plan for HIV and HIV-Related Research for FY 2021-2025. The funding provides a maximum of $400,000 over a two-year period, with applications due by September 7, 2025. Interested applicants can find more information and submission guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Notice of Intent to Publish a Funding Opportunity Announcement for Single Source for Continuation of the Integrated Islet Distribution Program (UC4)
    National Institutes of Health
    The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) for a single source cooperative agreement to continue the Integrated Islet Distribution Program (IIDP), with an estimated total funding of $3.3 million. This program aims to facilitate the distribution of human islets to biomedical researchers, thereby supporting critical research in diabetes by managing islet availability, investigator eligibility, and overseeing standardized analyses of islet preparations. Interested applicants, particularly those with expertise in live cell distribution and human islet biology, are encouraged to prepare for the upcoming application process, with the estimated synopsis posting date set for June 25, 2025, and the anticipated award date on July 1, 2026. For further inquiries, potential applicants can contact Dr. Thomas L. Eggerman at eggermant@nih.gov or by phone at 301-594-8814.
    Animal and Biological Material Resource Centers (P40) (Clinical Trials Not-Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Animal and Biological Material Resource Centers" (P40) aimed at supporting specialized colonies of laboratory animals and related resources to enhance scientific rigor and reproducibility in biomedical research. This funding initiative encourages applicants to propose centers that not only continue existing resources but also develop new ones based on the needs of the biomedical research community, providing unique animal models, informatics tools, and biological materials applicable across multiple NIH Institutes. The total funding commitment is anticipated to be $1.3 million over three years, with at least two grants awarded annually, and interested applicants must adhere to strict application guidelines, with submissions accepted until January 28, 2025. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) for the Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research, aimed at providing ongoing support for breeding colonies of Specific Pathogen Free (SPF) macaques essential for HIV/AIDS research. The funding will facilitate the breeding, maintenance, and allocation of these macaques to qualified researchers, ensuring rigorous health and genetic monitoring to mitigate risks associated with certain viruses that could affect research outcomes. These colonies play a critical role in advancing studies related to vaccine development and co-infection, underscoring their importance in the fight against HIV/AIDS. Interested applicants, specifically public and state-controlled institutions of higher education, must submit their proposals by January 7, 2027, and can find further details and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R24 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), is offering a funding opportunity (PAR-23-039) aimed at developing resources and technologies to enhance the rigor, reproducibility, and translatability of animal models in biomedical research. This initiative encourages applicants to propose broadly applicable technologies that address critical gaps in animal research, focusing on various animal models and ensuring that the proposed resources have significant impact across multiple NIH Institutes and Centers. Successful proposals should demonstrate the necessity and broad applicability of the resources, with project durations of up to four years and no budget limits, although requests exceeding $500,000 require prior approval. Interested applicants can find more information and submit inquiries via email to grantsinfo@nih.gov, with the application deadline set for May 25, 2025.