The Department of Health and Human Services, through the National Institutes of Health (NIH), is issuing a funding opportunity (PAR-25-331) for exploratory research on Alzheimer's disease (AD) and related dementias (ADRD). This initiative aims to advance understanding of these conditions by inviting applications for new methodologies, animal models, or techniques that require further preliminary data. Emphasizing the need for inclusive research, the announcement highlights the urgency to address health disparities among under-resourced populations. Key deadlines for applications start from February 11, 2025, with awards anticipated based on NIH budget availability. The maximum budget for projects is $275,000 over two years, and the program encourages organizations of varied backgrounds, especially those that historically serve diverse populations, to participate. Additionally, it lays out rigorous criteria for evaluating applications based on significance, innovation, scientific quality, and the expertise of the investigator(s). The overarching goal is to support interdisciplinary research and strengthen efforts to combat the impending public health crisis posed by AD and ADRD. The notice stresses compliance with NIH’s regulations and promotes early submission to accommodate potential application corrections.