The National Institutes of Health (NIH) is offering the NHLBI Outstanding Investigator Award (OIA), a federal grant aimed at enhancing scientific productivity and innovation in heart, lung, blood, and sleep (HLBS) research. This award is designed for experienced Program Directors/Principal Investigators (PDs/PIs) who currently hold at least two NHLBI R01-equivalent awards, providing long-term funding for up to seven years to support their research programs rather than specific projects. The OIA is significant as it allows researchers greater flexibility to explore innovative research directions while reducing the administrative burden associated with managing multiple grants. Interested applicants can find more information and submit inquiries via grantsinfo@nih.gov, with applications due by April 28, 2027, and an anticipated funding amount of up to $20 million annually across multiple fiscal years.