The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) titled "Social Disconnection and Suicide Risk in Late Life" (R21 Clinical Trial Optional), designed to spur research into the correlation between social disconnection and suicidal thoughts in older adults. Researchers are encouraged to explore mechanisms at various analytical levels—neurobiological, behavioral, and environmental—that affect suicide risk and resilience while considering health equity and disparities. The funding supports exploratory projects that lack preliminary data, with a budget of up to $275,000 over two years. Applicants must come from eligible organizations, including educational institutions, nonprofits, and government entities, and they need to complete various registrations before applying. The application process requires detailed design plans, adherence to rigorous ethical standards for research with human subjects, and a commitment to share research data post-study. Key deadlines include submission dates starting September 16, 2023, with awards expected to begin after thorough peer review. This initiative addresses rising suicide rates among older populations and the urgent need for effective interventions that leverage social connectivity for mental health support.