The National Institutes of Health (NIH) is releasing a funding opportunity aimed at investigating the connection between social disconnection and suicide risk in older adults. Specifically, the Social Disconnection and Suicide Risk in Late Life initiative encourages exploratory and developmental research (R21 grants) that identifies mechanisms by which social isolation increases suicide risk and how social integration may provide protective effects. The NOFO emphasizes the need for multi-level analysis, including neurobiological, behavioral, and environmental factors that contribute to this public health issue. With suicide rates rising significantly in this demographic, there is an urgent need for targeted interventions-though the evidence base currently remains thin. The funding seeks proposals that examine factors such as the impact of social disconnection on suicidality and disparities across different populations, including racial, gender, and socioeconomic dimensions. Selected projects may receive up to $275,000 over two years, with applications due from January 2025 onwards. Overall, the initiative aims to enhance understanding of critical intervention targets that can improve mental health outcomes among older adults facing suicide risk.