Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Individuals, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)
ID: 357730Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $6M

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357730

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-311.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Individuals, and Persons with Disabilities" through a cooperative agreement mechanism. This initiative aims to utilize NICHD clinical research network infrastructure to support multisite, investigator-initiated clinical trials and observational studies, focusing on improving health outcomes for vulnerable populations. The funding opportunity emphasizes the importance of diverse participant enrollment and collaboration, requiring applicants to develop a Plan for Enhancing Diverse Perspectives and a Data Management and Sharing Plan. The maximum funding amount is $6,250,000, with a project period of up to seven years, and applications are due by November 15, 2027. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at http://grants.nih.gov/grants/guide/pa-files/PAR-25-311.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-311-Full-Announcement.html
    PAR-25-311.html
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), announces a funding opportunity focused on leveraging clinical research network infrastructure to conduct innovative research involving women, children, pregnant and lactating individuals, and persons with disabilities. This funding opportunity utilizes a bi-phasic UG3/UH3 mechanism to support multisite, investigator-initiated clinical trials and observational studies, promoting diverse participant enrollment and advanced methodologies. Applications must involve NICHD-supported networks, fostering collaboration with junior investigators and emphasizing the enhancement of diverse perspectives throughout the research process. Key objectives include improving health outcomes and developing strategies to address critical health issues affecting vulnerable populations. The maximum project period available is seven years, with direct costs capped at $6,250,000. This NOFO replaces a previous announcement and incorporates feedback to enhance the efficiency and effectiveness of proposed studies. Additionally, applicants must adhere to a Plan for Enhancing Diverse Perspectives and provide a detailed Data Management and Sharing Plan to ensure broad access to research findings and data, underscoring transparency and collaboration in clinical research under the NIH mandate.
    Similar Opportunities
    Multisite Clinical Research: Leveraging Network Infrastructure to Advance Research for Women, Children, Pregnant and Lactating Individuals, and Persons with Disabilities (U01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity (PAR-23-037) aimed at promoting multisite clinical trials and observational studies focused on women, children, pregnant and lactating individuals, and persons with disabilities. The initiative seeks to enhance the rigor and reproducibility of clinical trial protocols, facilitate data sharing, and increase the involvement of diverse populations in research through the utilization of NICHD-supported Network infrastructure. This funding opportunity supports projects for up to five years, with budgets reflecting actual needs, and requires a rigorous pre-application process starting with a Letter of Inquiry. Interested applicants can find more information and submit inquiries via grantsinfo@nih.gov, with ongoing application cycles and a close date set for May 7, 2026.
    Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)" aimed at advancing precision medicine for pregnant individuals, lactating persons, and children. This grant seeks to support innovative research that develops novel tools and technologies, enhances understanding of drug mechanisms, and improves therapeutic options for these populations, particularly those with disabilities. The initiative is part of the R21 Exploratory/Developmental Research Grants program, with a funding cap of $275,000 over a potential two-year period, and requires a Data Management and Sharing Plan as part of the application process. Interested applicants can find more information and submit inquiries via email at grantsinfo@nih.gov, with the application deadline set for May 7, 2026.
    Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)" aimed at advancing research in drug safety and effectiveness for pregnant individuals, lactating persons, and children. This initiative seeks to support innovative projects that develop novel methodologies, enhance understanding of drug mechanisms, and promote precision medicine to address significant unmet medical needs in maternal and pediatric health. Eligible applicants include a wide range of institutions, such as historically black colleges and universities, tribal colleges, and various nonprofit organizations, with funding available up to $275,000 over a two-year period. Interested parties should note that applications are accepted until December 16, 2026, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    NICHD Small Research Grant Program (R03 Clinical Trial Required)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering the NICHD Small Research Grant Program (R03 Clinical Trial Required) to support clinical trials aligned with the mission of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). This program aims to fund small-scale research projects, including pilot studies and methodological development, with a maximum budget of $50,000 per year for up to two years. The funding is crucial for advancing knowledge in human development fields, particularly in childhood development and rehabilitation medicine. Interested applicants must adhere to specific guidelines and register with Grants.gov and eRA Commons, with the application window opening on January 16, 2025, and closing on January 8, 2028. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    NICHD Research Education Programs (R25 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) for Research Education Programs (R25), aimed at enhancing training for the biomedical, behavioral, and clinical research workforce. This grant supports innovative educational activities focused on research skills development, with a funding ceiling of $150,000 per year for a maximum of five years, and is not intended for clinical trials. The initiative emphasizes the importance of creating accessible educational opportunities that foster diversity and collaboration among participants, ranging from upper undergraduates to faculty. Interested applicants can find more information and application guidelines at the provided link, with proposals due by May 25, 2025, and inquiries directed to grantsinfo@nih.gov.
    Health and Health Care Disparities Among Persons Living with Disabilities (R01 - Clinical Trials Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Health and Health Care Disparities Among Persons Living with Disabilities" (R01 - Clinical Trials Optional) aimed at supporting innovative research that addresses the health challenges faced by individuals with disabilities, particularly in relation to race, ethnicity, and socio-economic status. The initiative seeks to investigate the systemic factors that adversely affect the health and well-being of this population, with a focus on understanding barriers to healthcare access and developing effective interventions to mitigate disparities. This funding opportunity is crucial for enhancing healthcare outcomes for marginalized groups living with disabilities through collaborative, community-engaged research. Interested applicants can apply for grants with an award ceiling of $500,000, and the application process opened on January 5, 2024, with a submission deadline of November 5, 2026. For further inquiries, applicants may contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-309.html.
    Archiving and Documenting Child Health and Human Development Data Sets (R03 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Archiving and Documenting Child Health and Human Development Data Sets (R03 Clinical Trial Not Allowed)" aimed at supporting the archiving and documentation of existing data sets to facilitate secondary analysis by the scientific community. This initiative, under the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), prioritizes the management of data collected with NICHD support, encouraging activities such as data cleaning, harmonization, and the development of user documentation while ensuring adherence to data sharing policies and participant confidentiality. Eligible applicants include a wide range of organizations, with a funding limit of $50,000 available over a maximum of two years, and applications must be submitted by November 17, 2025, with funding anticipated to begin in early 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Research Opportunities for New and 'At-Risk' Investigators to Promote Workforce Diversity" (PAR-22-181), aimed at enhancing the diversity of the biomedical research workforce. This initiative invites R01 grant applications for independent research projects that align with the scientific missions of participating NIH Institutes or Centers, specifically targeting New Investigators and At-Risk Investigators from underrepresented backgrounds, including racial and ethnic minorities and individuals with disabilities. The program emphasizes the importance of addressing health disparities and promoting diverse representation in science, with funding allocations of up to $10 million for NINDS and $5 million for NIDA/NIMH, among others, for a maximum project period of five years. Interested applicants should submit their proposals by June 6, 2025, and can direct inquiries to the NIH OER Webmaster at OERWebmaster03@od.nih.gov for further information.
    NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering the "NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)" to support the development and dissemination of vital bioinformatics resources related to embryonic developmental processes. The primary objective of this funding opportunity is to ensure the ongoing operation, maintenance, and enhancement of unique database resources that are crucial for biomedical research utilizing animal models, while promoting user training, data curation, and interoperability with other NIH bioinformatics tools. This initiative is significant for advancing research in the field and adheres to FAIR data principles, with funding amounts ranging from $500,000 to $1,750,000 annually for a maximum project period of five years. Interested applicants should note that the application submission deadlines begin on December 25, 2024, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Model Continuums of Care Initiative (MCCI) to Advance Health Equity and End Health Disparities Among Women and Girls in Racial/Ethnic Minority and Other Underserved Communities (U34 Clinical Trials Required)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled the "Model Continuums of Care Initiative (MCCI)" aimed at advancing health equity and reducing health disparities among women and girls in racial/ethnic minority and underserved communities. This initiative focuses on the planning phase of establishing integrated models of care that address multi-morbidities, particularly for women aged 15-44, by combining preventive health services, primary care, and mental health care. The program encourages innovative research and requires applicants to include a "Plan for Enhancing Diverse Perspectives" to promote inclusivity, with funding capped at $225,000 annually for up to three years. Interested applicants must submit their proposals by February 19, 2025, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.