The National Institutes of Health (NIH) is inviting applications for the Community-Partnered Nursing Research Centers (P20 Clinical Trial Optional) grant, aimed at establishing innovative nursing-led research centers that focus on community-partnered research to tackle persistent health challenges. Applicants are required to propose strategies that enhance research infrastructure within Schools or Colleges of Nursing, develop nurse-led interdisciplinary teams, and engage the community meaningfully throughout all research activities, including the execution of at least one pilot project that generates preliminary data for future NIH submissions. This initiative is critical for fostering sustainable research infrastructure and improving health outcomes in diverse communities. The grant offers a maximum funding amount of $500,000 per year for a project period of up to five years, with applications due by May 7, 2028. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-25-439.html.