The National Institutes of Health (NIH) has announced an opportunity for urgent competitive revisions to existing research grants and cooperative agreements, aimed at addressing unforeseen public health crises. This funding allows principal investigators to submit applications for modifications to their active grants to meet immediate needs that were not anticipated during the original grant application process. The opportunity is particularly significant as it underscores the NIH's commitment to adapting research efforts in response to critical public health situations, with eligibility extending to a wide range of organizations, including higher education institutions, nonprofits, and various government entities. Interested applicants should note that there are no specific budget limits, and applications must adhere to the new "FORMS-H" guidelines, with a submission deadline of October 25, 2025. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PA-23-044.html.