The National Institutes of Health (NIH) is offering a funding opportunity for competing revisions to existing NIH single project research grants and cooperative agreements, with a focus on clinical trials. This initiative allows eligible organizations to apply for additional funding to expand ongoing projects under specific NIH Institutes or Centers, following the guidelines set forth in the Notice of Special Interest (NOSI). The application process is electronic, requiring submissions via the NIH ASSIST system or Grants.gov, and will be evaluated based on scientific merit, innovation, and relevance to NIH priorities. Interested applicants must submit their proposals by November 24, 2026, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov for further assistance.