The National Institutes of Health (NIH), specifically the National Institute on Drug Abuse (NIDA), has announced the Cutting-Edge Basic Research Awards (CEBRA), aimed at fostering innovative research in substance use disorders (SUDs). This funding opportunity invites exploratory applications that focus on high-risk, high-impact research not currently represented in NIDA’s portfolio. Proposed studies should introduce revolutionary methodologies or test transformative hypotheses despite lacking extensive preliminary data. The program encourages participation from a diverse range of institutions and research backgrounds to stimulate novel insights into SUD etiology and treatment, particularly emphasizing the integration of various scientific disciplines. The maximum budget for each two-year project is $275,000, with no more than $150,000 requested in a single year. Applications are due by February 10, 2025, with an expiration date set for August 12, 2027. Ensuring compliance with application guidelines is essential, as oversight denotes strict adherence to the NIH Grants Policy Statement. This initiative underscores the commitment to accelerating advancements in addiction research through innovative scientific inquiry and collaboration across diverse academic and research institutions.