The National Institutes of Health (NIH), through the National Institute on Drug Abuse (NIDA), has announced the Cutting-Edge Basic Research Awards (CEBRA) aimed at promoting innovative research in the field of substance use disorders (SUDs). This funding opportunity invites exploratory applications that focus on high-risk, high-impact research not currently represented in NIDA’s portfolio, encouraging the development of revolutionary methodologies or the testing of transformative hypotheses. The program seeks to stimulate novel insights into the etiology and treatment of SUDs by integrating diverse scientific disciplines, with a maximum budget of $275,000 for each two-year project, allowing no more than $150,000 to be requested in a single year. Applications are due by February 10, 2025, and the funding opportunity will remain open until August 12, 2027; for further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.