The National Institutes of Health (NIH) is offering a funding opportunity titled "Miniaturization and Automation of Tissue Chip Systems (MATChS)" aimed at U.S. small business concerns through STTR Phase I and II cooperative agreements. The initiative seeks to develop innovative microphysiological systems (MPS) that replicate human organ functions for drug discovery and biomedical research, addressing the limitations of traditional methods that are often costly and time-consuming. This funding opportunity is crucial for advancing tissue chip technology, enhancing the accessibility and usability of these systems in research, and supporting safe therapeutic assessments. Interested applicants can apply for a total funding commitment of up to $2.15 million, with key submission dates including an open date for applications on January 22, 2024, and a closing date of February 23, 2026. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-23-018.html.