The Agency for Healthcare Research and Quality (AHRQ) is inviting grant applications for Large Research Projects (R01) aimed at advancing knowledge in the detection, prevention, and reduction of Healthcare-Associated Infections (HAIs). This funding opportunity emphasizes research that addresses significant healthcare challenges, particularly in settings such as hospitals and long-term care facilities, while promoting equity and including priority populations. Eligible applicants include educational institutions, nonprofits, and governmental agencies, with grant budgets reaching up to $500,000 per year for projects lasting no more than five years. Interested parties should submit their applications through Grants.gov by the deadline of May 26, 2025, and can direct inquiries to Grant_Queries@ahrq.hhs.gov for further information.