The Agency for Healthcare Research and Quality (AHRQ) has announced a funding opportunity for Large Research Projects aimed at combating antibiotic-resistant bacteria (CARB). This initiative invites grant applications focused on promoting appropriate antibiotic use, reducing the transmission of resistant bacteria, and preventing healthcare-associated infections across various healthcare settings, including acute care hospitals and long-term care facilities. With over 35,000 deaths annually in the U.S. attributed to antibiotic resistance, this research is critical for enhancing healthcare delivery. Interested applicants can apply for grants with project budgets capped at $2.5 million over five years, and must adhere to specific guidelines, including data management plans. The application deadline is October 30, 2026, and further details can be obtained by contacting AHRQ at Grant_Queries@ahrq.hhs.gov or visiting the additional information link provided in the announcement.