The Department of Health and Human Services, through the Agency for Healthcare Research and Quality (AHRQ), is announcing a Notice of Funding Opportunity (NOFO) for Health Services Research Demonstration and Dissemination Grants (R18). This initiative invites research applications focused on improving healthcare quality, patient safety, and whole-person healthcare delivery across various settings such as hospitals, long-term care, and home healthcare. The grant supports both new and renewal applications, with a budget cap of $400,000 per year for up to five years. Eligible applicants include educational institutions, non-profits, local and state governments, and tribal organizations, although for-profit entities may only participate as subcontractors. The application process requires adherence to specific guidelines, including demonstrating how the proposed work aligns with AHRQ’s research priorities, particularly concerning priority populations. Key dates for submissions begin with an opening date of March 20, 2024, and applications are due by May 25, 2024. The evaluation will assess scientific merit using criteria such as significance, investigator qualifications, innovation, approach, and the research environment. AHRQ emphasizes a commitment to diverse populations and mandates clear data management plans for disseminating research findings.