Precision Approaches in Radiation Synthetic Combinations (PAIRS, R21 Clinical Trial Optional)
ID: 341118Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $275K

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/341118

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-22-199.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Precision Approaches in Radiation Synthetic Combinations (PAIRS, R21 Clinical Trial Optional)" aimed at advancing cancer treatment through innovative research. This initiative seeks applications that explore actionable synthetic vulnerabilities in conjunction with tumor responses to radiation therapy, with a focus on developing effective radiation-synthetic combination strategies for precision medicine. The program is particularly relevant for enhancing cancer therapeutics by leveraging the unique responses of tumors to radiation, and it encourages research from pre-clinical to early clinical trial stages. Eligible applicants can request up to $275,000 over a two-year period, with a maximum of $200,000 in any single year, and the application deadline is September 7, 2025. For further inquiries, interested parties can contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov or refer to the full announcement at http://grants.nih.gov/grants/guide/pa-files/PAR-22-199.html.

    Point(s) of Contact
    OERWebmaster03@od.nih.gov
    Files
    Title
    Posted
    PAR-22-199-Full-Announcement.html
    PAR-22-199.html
    The National Cancer Institute (NCI) is soliciting applications for the Precision Approaches in Radiation Synthetic Combinations (PAIRS) program, a funding opportunity under the R21 Exploratory/Developmental Research Grant mechanism. This initiative aims to explore actionable vulnerabilities in cancer treatment through the synergy between radiation therapy and targeted agents, thereby enhancing precision medicine. The program encourages research from pre-clinical to early clinical trial stages, focusing on developing radiation-synthetic strategies that leverage the unique responses of tumors to radiation. Eligible applicants include various institutions, nonprofits, and for-profit organizations. Each application can request up to $275,000 over two years, with no more than $200,000 in a single year. The application process requires adherence to specific guidelines, and successful applications will undergo peer review for scientific merit and relevance to the initiative's goals. The PAIRS program emphasizes the need for innovative approaches to cancer treatment, targeting processes like epigenetic and metabolic reprogramming, while applications integrating radiation into their designs will be prioritized. This funding opportunity represents a significant step towards advancing cancer therapeutics through enhanced understanding of radiation's role in synthetic lethal approaches.
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