The National Institutes of Health is offering a grant opportunity titled "Precision Approaches in Radiation Synthetic Combinations (PAIRS, R21 Clinical Trial Optional)". This grant aims to support research projects that investigate actionable synthetic vulnerabilities that can be conditionally paired with tumor responses to radiation therapy. The goal of the program is to develop radiation-synthetic combination strategies and facilitate their adoption into the precision medicine toolkit for the development of new and effective anticancer treatments. The grant does not require cost sharing or matching. The maximum award ceiling is $275,000. The grant is open to various eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, Eligible Agencies of the Federal Government, Faith-based or Community-based Organizations, Hispanic-serving Institutions, Historically Black Colleges and Universities, Indian/Native American Tribal Governments, Non-domestic (non-U.S.) Entities, Regional Organizations, Tribally Controlled Colleges and Universities, and U.S. Territories or Possessions. The closing date for applications is September 7, 2025. For more information and to apply, visit the following link: http://grants.nih.gov/grants/guide/pa-files/PAR-22-199.html. For any inquiries, contact NIH OER Webmaster at OERWebmaster03@od.nih.gov.