The National Institutes of Health (NIH) is offering a funding opportunity titled "Precision Approaches in Radiation Synthetic Combinations (PAIRS, R21 Clinical Trial Optional)" aimed at advancing cancer treatment through innovative research. This initiative seeks applications that explore actionable synthetic vulnerabilities in conjunction with tumor responses to radiation therapy, with a focus on developing effective radiation-synthetic combination strategies for precision medicine. The program is particularly relevant for enhancing cancer therapeutics by leveraging the unique responses of tumors to radiation, and it encourages research from pre-clinical to early clinical trial stages. Eligible applicants can request up to $275,000 over a two-year period, with a maximum of $200,000 in any single year, and the application deadline is September 7, 2025. For further inquiries, interested parties can contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov or refer to the full announcement at http://grants.nih.gov/grants/guide/pa-files/PAR-22-199.html.