The Department of Health and Human Services, through the National Cancer Institute (NCI), announces the funding opportunity PAR-23-255 for the Secondary Analysis and Integration of Existing Data related to cancer risk and outcomes. This initiative encourages applications for innovative analysis of existing datasets across various domains, including clinical, behavioral, and genomic data to address significant questions in cancer research. Eligible applicants can seek funding up to $275,000 over two years without conducting clinical trials. The emphasis is on leveraging previously collected data to enhance understanding of cancer risks, progression, and disparities, particularly among underrepresented populations. Applications should conform to extensive instructions outlined in the NIH Grants Policy Statement. This NOFO aims to maximize the utility of available data and foster advancements in cancer prevention and treatment strategies, supporting innovative methods through careful integration and analysis of diverse data sources. Key dates for application submissions are set, with the first due date on October 16, 2023, and funding contingent upon the merit of applications received. The directive aligns with ongoing federal efforts to utilize shared scientific data effectively, thereby expediting research progress in cancer control.