The National Institutes of Health (NIH) is offering the Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) program through the National Institute of Environmental Health Sciences (NIEHS) to support exceptional investigators in the field of environmental health sciences. This program aims to provide researchers with the intellectual and administrative freedom to pursue innovative research directions, consolidating their existing projects into a single flexible award that allows for substantial effort toward transformative research over an eight-year funding period, with an annual budget capped at $600,000, or up to $750,000 for consolidating existing projects. The RIVER program emphasizes long-term impact in environmental health, encouraging ambitious scientific advances while promoting mentorship and diversity within research initiatives. Interested applicants must have prior significant support from NIEHS and commit at least 50% effort to their proposed project, with applications opening on October 1, 2024, and due by November 2, 2024. For further information, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the program's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-ES-24-004.html.