The National Institutes of Health (NIH) is announcing a funding opportunity titled "Genomic Variant Interactions With Other Variants Or The Environment," aimed at studying the effects of genetic and environmental interactions on genomic variant impact. This initiative seeks to establish research frameworks that will experimentally test combinations of variants to identify significant interactions that could enhance the understanding of Genome-wide Association Studies (GWAS) and improve polygenic scores. The total estimated funding for this program is $10 million, with approximately five awards expected to be made. Interested applicants, including small businesses and eligible foreign entities, should prepare for the anticipated Notice of Funding Opportunity (NOFO) publication in 2025, with applications due later that year. For further inquiries, contact Mike Pazin at michael.pazin@nih.gov or by phone at 301-480-2629.