IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed)
ID: 358855Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Small Businesses

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/358855
Timeline
    Description

    The National Institutes of Health (NIH) is seeking applications for the Impact of Genomic Variation on Function (IGVF) Data and Coordinating Center (DACC) through a cooperative agreement. The DACC will serve as the central hub for the IGVF Consortium, tasked with developing a comprehensive data portal and cataloging variant impacts, while also facilitating consortium activities and collaborations within the broader research community. This initiative is crucial for enhancing the understanding of genomic variation and its implications in health. The estimated total program funding is $1,200,000, with one award anticipated, and the application process is expected to open in 2025, with a due date later that year. For further inquiries, interested applicants can contact Dr. Stephanie A. Morris at morriss2@mail.nih.gov or by phone at 301-435-5738.

    Point(s) of Contact
    Stephanie A. Morris, Ph.D. National Human Genome Research Institute (NHGRI)
    (301) 435-5738
    morriss2@mail.nih.gov
    Files
    No associated files provided.
    Similar Opportunities
    Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)" through a cooperative agreement. This initiative aims to solicit applications for research focused on developing, applying, and testing predictive models to analyze the effects of genomic variation on genome function, with funded centers becoming part of the Impact of Genomic Variation on Function (IGVF) Consortium. The total estimated program funding is $5 million, with approximately five awards expected, and the application process is anticipated to open in 2025, with a due date later that year. Interested applicants can reach out to Daniel Gilchrist, Ph.D., at daniel.gilchrist@nih.gov or by phone at 301-412-2926 for further information.
    Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype," aimed at small businesses. This initiative seeks to support research that characterizes genomic variation and assesses the impact of individual variants on genome function through high-throughput methods, data collection on molecular and cellular phenotypes, and the development of robust data processing pipelines. The initiative is part of the Impact of Genomic Variation on Function (IGVF) Consortium, which will facilitate collaboration among funded centers to ensure resource accessibility and shared analysis strategies. The estimated total program funding is $3 million, with five awards expected, and the application process is anticipated to open in 2025, with a due date later that year. For further inquiries, interested applicants can contact Dr. Stephanie A. Morris at morriss2@mail.nih.gov or by phone at 301-435-5738.
    The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Data Coordinating Center
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a cooperative agreement opportunity for the establishment of the Data Coordinating Center (DCC) for the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC). The DCC will play a crucial role in coordinating collaborations among genetic research centers, managing participant enrollment, biospecimen collections, and overseeing data submission to central databases, all aimed at advancing research in inflammatory bowel disease (IBD). This initiative is vital for improving medical management and precision medicine for IBD patients, as it seeks to develop new predictors of disease outcomes through the integration of genetic, clinical, and environmental data. The estimated total funding for this program is $1,600,000, with one award expected to be made. Interested applicants can reach out to Dr. Ludmila Pawlikowska at Ludmila.pawlikowska@nih.gov or by phone at 301-480-9372 for further information. The application period is open until November 1, 2026, with an anticipated award date of July 1, 2027.
    GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for the establishment of the GREGoRi Data Coordination and Outreach Center, aimed at advancing the Genomics Research to Elucidate the Genetics of Rare Disease (GREGoR) program. This initiative seeks to enhance the diagnosis of rare genetic disorders by developing innovative tools and analytical methods to identify causal genes and variants, with the center serving as the primary coordination hub for data and resources generated by the GREGoRi program. The total estimated funding for this cooperative agreement is $2 million, with one award anticipated, and applications are expected to be due in 2026 following the publication of the Notice of Funding Opportunity (NOFO) in 2025. For further inquiries, interested applicants can contact Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275.
    Centers of Excellence in Genomic Science (CEGS)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the Centers of Excellence in Genomic Science (CEGS) program, aimed at fostering interdisciplinary research teams to tackle significant biomedical challenges from a genomics perspective. The initiative seeks to develop innovative concepts, methods, and technologies that can lead to transformative advancements in genomic science, genomic medicine, and computational genomics, with a focus on high-risk, high-reward projects that are unlikely to be pursued through standard funding mechanisms. With an estimated total program funding of $5 million and the expectation of awarding two grants, interested applicants can reach out to Stephanie A. Morris at morriss2@mail.nih.gov or call 301-435-5738 for further information. The application process is set to open with a synopsis posting on March 25, 2026, and will close on June 24, 2026, with awards anticipated by April 1, 2027.
    ancient DNA for Modern Genomics (aDMG) Data Generation and Resource Center
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing an upcoming funding opportunity for the establishment of an ancient DNA for Modern Genomics (aDMG) Data Generation and Resource Center. This initiative aims to create an ethical resource of ancient and historical human DNA data to enhance research on contemporary human traits and biology, with a focus on producing high-quality whole-genome sequence data from approved ancient DNA sources. The program is significant for advancing studies in population genomics and human evolution, encouraging collaborations among experts in DNA sequencing, computational genomics, and related fields. The estimated total program funding is $2,750,000, with one award expected, and interested applicants should prepare for the application process, which will open following the publication of the Notice of Funding Opportunity (NOFO) in December 2025, with a closing date in March 2026. For further inquiries, potential applicants can contact Jennifer Troyer at jennifer.troyer@nih.gov or by phone at 301-312-3276.
    The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genomic Research Centers
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a federal grant opportunity titled "The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genomic Research Centers," aimed at advancing research in inflammatory bowel disease (IBD). This initiative seeks to establish up to seven Genomic Research Centers that will leverage patient cohorts, biospecimens, and data science to explore genetic, clinical, and environmental factors influencing IBD, with the goal of developing new predictors for disease outcomes and enhancing precision medicine for patients. The total estimated funding for this program is $6.4 million, with nine awards expected to be granted, and interested applicants can reach out to Dr. Ludmila Pawlikowska at ludmila.pawlikowska@nih.gov or by phone at 301-480-9372 for further information. Key deadlines include an estimated synopsis post date of August 1, 2026, and a close date of November 1, 2026, with project start anticipated on July 1, 2027.
    GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity for the establishment of the GREGoRi Technology Integration Center (TechIC) under the Genomics Research to Elucidate the Genetics of Rare Disease (GREGoR) program. This initiative aims to advance the diagnosis of rare genetic disorders by developing standards and best practices for new molecular methods, ultimately producing a multidimensional dataset to support the creation and evaluation of innovative diagnostic tools. The total estimated funding for this cooperative agreement is $3 million, with one award anticipated, and applications are expected to be due in 2026 following the publication of the Notice of Funding Opportunity (NOFO) in 2025. For further inquiries, interested applicants can contact Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275.
    Illuminating AD/ADRD Genome to Enable Precision Genomic Medicine
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a forthcoming funding opportunity titled "Illuminating AD/ADRD Genome to Enable Precision Genomic Medicine," aimed at supporting integrative, cross-disciplinary research projects focused on understanding the genomic factors involved in Alzheimer's Disease (AD) and Alzheimer's Disease Related Dementias (ADRD). The initiative seeks to leverage innovative techniques and advanced analytical methods, including machine learning and comparative genomic analysis, to explore the genomic drivers of neurodegeneration through sophisticated disease models and interdisciplinary approaches. This cooperative agreement does not require cost sharing and is open to a wide range of eligible applicants, including non-domestic entities and tribal governments, with applications expected to be solicited starting in August 2026. For further inquiries, interested parties may contact Dr. Alison Yao at 301-827-7264 or via email at yaoal@nia.nih.gov.
    Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Genomic Variant Interactions With Other Variants Or The Environment," aimed at studying the effects of genetic and environmental interactions on genomic variant impact. This initiative seeks to establish research frameworks that will experimentally test combinations of variants to identify significant interactions that could enhance the understanding of Genome-wide Association Studies (GWAS) and improve polygenic scores. The total estimated funding for this program is $10 million, with approximately five awards expected to be made. Interested applicants, including small businesses and eligible foreign entities, should prepare for the anticipated Notice of Funding Opportunity (NOFO) publication in 2025, with applications due later that year. For further inquiries, contact Mike Pazin at michael.pazin@nih.gov or by phone at 301-480-2629.