Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels
ID: 359827Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Small Businesses

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/359827
Timeline
    Description

    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the establishment and continuation of Genomic Curation Expert Panels under the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The objective of this funding opportunity is to solicit applications from small businesses to manually curate, review, and define the clinical relevance of genes and variants, addressing the challenge of genomic variants with unknown significance that hinder advancements in genomic and precision medicine. This initiative is crucial for enhancing the understanding of the links between genes, variants, and diseases, ultimately contributing to a centralized public resource for expert-curated genetic data. The estimated total program funding is $880,000, with four expected awards, and interested applicants can contact Dr. Julia Jiaqi O'Reilly at Jiaqi.OReilly@nih.gov or 240-328-8649 for further information. Key deadlines include an estimated synopsis post date of March 25, 2026, and a close date of May 25, 2026, with awards anticipated by April 1, 2027.

    Point(s) of Contact
    Julia Jiaqi O’Reilly, PhD Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
    (240) 328-8649
    Jiaqi.OReilly@nih.gov
    Files
    No associated files provided.
    Similar Opportunities
    Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is set to announce a funding opportunity for the Genome Sequencing Center as part of the Gabriella Miller Kids First Pediatric Research Program, aimed at advancing research into childhood cancer and congenital anomalies. This initiative will support the addition of data to existing resources, enhance data types as technologies evolve, and incorporate clinic-based data sources to better understand the genetic pathways of these disorders. With an estimated total program funding of $6.6 million, this cooperative agreement does not require cost sharing and is open to small businesses. Interested applicants are encouraged to prepare for the upcoming Notice of Funding Opportunity (NOFO), with an estimated synopsis posting date of July 30, 2025, and a closing date of October 30, 2025. For further inquiries, potential applicants can contact Dr. Concepcion R. Nierras at 301-435-5840 or via email at concepcion.nierras@nih.gov.
    Clinical Data Ecosystem for Genomics (CDEG)
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the Clinical Data Ecosystem for Genomics (CDEG), aimed at establishing a network to enhance the integration and sharing of genomic sequencing data among healthcare providers, labs, and patients. The initiative seeks to reduce barriers to clinical data sharing by creating a pilot ecosystem that demonstrates best practices, developing standardized APIs, and producing open-source clinical software applications that facilitate access to genomic data across various healthcare settings. This cooperative agreement is particularly relevant for small businesses with expertise in genomic medicine, data science, and health information exchange, and interested applicants are encouraged to begin forming collaborations in anticipation of the application process. For further inquiries, potential applicants can contact Jennifer Troyer at jennifer.troyer@nih.gov or by phone at 301-312-3276. The estimated synopsis post date is December 1, 2025, with applications expected to close by March 2, 2026, and awards anticipated by October 30, 2026.
    Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype," aimed at small businesses. This initiative seeks to support research that characterizes genomic variation and assesses the impact of individual variants on genome function through high-throughput methods, data collection on molecular and cellular phenotypes, and the development of robust data processing pipelines. The initiative is part of the Impact of Genomic Variation on Function (IGVF) Consortium, which will facilitate collaboration among funded centers to ensure resource accessibility and shared analysis strategies. The estimated total program funding is $3 million, with five awards expected, and the application process is anticipated to open in 2025, with a due date later that year. For further inquiries, interested applicants can contact Dr. Stephanie A. Morris at morriss2@mail.nih.gov or by phone at 301-435-5738.
    Centers for Genomics Research Capacity Building
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Centers for Genomics Research Capacity Building," aimed at enhancing genomics research capabilities at biomedical institutions. This initiative seeks applications from small businesses to establish Genomic Research Centers that will support interdisciplinary teams in developing innovative genomic research projects addressing critical issues such as genomic technology, disease genomics, and the ethical implications of genomic research. With an estimated total program funding of $5 million and the expectation of awarding three grants, interested applicants are encouraged to begin forming collaborations and developing proposals, with the anticipated synopsis posting date on December 1, 2025, and a closing date for applications on March 2, 2026. For further inquiries, potential applicants can contact Jennifer Troyer at jennifer.troyer@nih.gov or by phone at 301-312-3276.
    GREGoRi Innovation Projects (U01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is set to announce a funding opportunity titled "GREGoRi Innovation Projects (U01 Clinical Trial Optional)" aimed at soliciting applications for research on proof of concept studies that explore innovative strategies for identifying genes or variants associated with rare genetic disorders. This initiative seeks to advance beyond traditional DNA sequencing methods by incorporating emerging molecular technologies, such as multi-omics and RNA-seq, to enhance the understanding of these disorders. The funding will be provided through a cooperative agreement, with no cost-sharing requirement, and is particularly targeted at small businesses engaged in health-related research. Interested applicants should prepare for the anticipated Notice of Funding Opportunity (NOFO) publication in 2025, with applications due in 2026, and can reach out to Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275 for further information.
    GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity for the establishment of the GREGoRi Technology Integration Center (TechIC) under the Genomics Research to Elucidate the Genetics of Rare Disease (GREGoR) program. This initiative aims to advance the diagnosis of rare genetic disorders by developing standards and best practices for new molecular methods, ultimately producing a multidimensional dataset to support the creation and evaluation of innovative diagnostic tools. The total estimated funding for this cooperative agreement is $3 million, with one award anticipated, and applications are expected to be due in 2026 following the publication of the Notice of Funding Opportunity (NOFO) in 2025. For further inquiries, interested applicants can contact Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275.
    GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for the establishment of the GREGoRi Data Coordination and Outreach Center, aimed at advancing the Genomics Research to Elucidate the Genetics of Rare Disease (GREGoR) program. This initiative seeks to enhance the diagnosis of rare genetic disorders by developing innovative tools and analytical methods to identify causal genes and variants, with the center serving as the primary coordination hub for data and resources generated by the GREGoRi program. The total estimated funding for this cooperative agreement is $2 million, with one award anticipated, and applications are expected to be due in 2026 following the publication of the Notice of Funding Opportunity (NOFO) in 2025. For further inquiries, interested applicants can contact Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275.
    Centers of Excellence in Genomic Science (CEGS)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the Centers of Excellence in Genomic Science (CEGS) program, aimed at fostering interdisciplinary research teams to tackle significant biomedical challenges from a genomics perspective. The initiative seeks to develop innovative concepts, methods, and technologies that can lead to transformative advancements in genomic science, genomic medicine, and computational genomics, with a focus on high-risk, high-reward projects that are unlikely to be pursued through standard funding mechanisms. With an estimated total program funding of $5 million and the expectation of awarding two grants, interested applicants can reach out to Stephanie A. Morris at morriss2@mail.nih.gov or call 301-435-5738 for further information. The application process is set to open with a synopsis posting on March 25, 2026, and will close on June 24, 2026, with awards anticipated by April 1, 2027.
    Continued Development of the Gabriella Miller Kids First Pediatric Data Resource Center (U2C Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity for the Continued Development of the Gabriella Miller Kids First Pediatric Data Resource Center through a Cooperative Agreement. This initiative aims to enhance the Pediatric Data Resource, focusing on expanding data sharing, providing training in cloud-based computational analysis, and facilitating data use for researchers with limited bioinformatics training, ultimately contributing to advancements in understanding childhood cancer and congenital anomalies. The estimated total program funding is $5,200,000, with applications not currently being solicited; however, potential applicants are encouraged to prepare collaborative projects in anticipation of the upcoming Notice of Funding Opportunity (NOFO), which is expected to be published by July 30, 2025, with a closing date for synopsis on October 30, 2025. For further inquiries, interested parties may contact Dr. Concepcion R. Nierras at 301-435-5840 or via email at concepcion.nierras@nih.gov.
    IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is seeking applications for the Impact of Genomic Variation on Function (IGVF) Data and Coordinating Center (DACC) through a cooperative agreement. The DACC will serve as the central hub for the IGVF Consortium, tasked with developing a comprehensive data portal and cataloging variant impacts, while also facilitating consortium activities and collaborations within the broader research community. This initiative is crucial for enhancing the understanding of genomic variation and its implications in health. The estimated total program funding is $1,200,000, with one award anticipated, and the application process is expected to open in 2025, with a due date later that year. For further inquiries, interested applicants can contact Dr. Stephanie A. Morris at morriss2@mail.nih.gov or by phone at 301-435-5738.