GREGoRi Innovation Projects (U01 Clinical Trial Optional)
ID: 359644Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Small Businesses

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/359644
Timeline
    Description

    The National Institutes of Health (NIH) is set to announce a funding opportunity titled "GREGoRi Innovation Projects (U01 Clinical Trial Optional)" aimed at soliciting applications for research on proof of concept studies that explore innovative strategies for identifying genes or variants associated with rare genetic disorders. This initiative seeks to advance beyond traditional DNA sequencing methods by incorporating emerging molecular technologies, such as multi-omics and RNA-seq, to enhance the understanding of these disorders. The funding will be provided through a cooperative agreement, with no cost-sharing requirement, and is particularly targeted at small businesses engaged in health-related research. Interested applicants should prepare for the anticipated Notice of Funding Opportunity (NOFO) publication in 2025, with applications due in 2026, and can reach out to Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275 for further information.

    Point(s) of Contact
    Lisa H. Chadwick National Human Genome Research Institute (NHGRI)
    (301) 435-7275
    lisa.chadwick@nih.gov
    Files
    No associated files provided.
    Similar Opportunities
    GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity for the establishment of the GREGoRi Technology Integration Center (TechIC) under the Genomics Research to Elucidate the Genetics of Rare Disease (GREGoR) program. This initiative aims to advance the diagnosis of rare genetic disorders by developing standards and best practices for new molecular methods, ultimately producing a multidimensional dataset to support the creation and evaluation of innovative diagnostic tools. The total estimated funding for this cooperative agreement is $3 million, with one award anticipated, and applications are expected to be due in 2026 following the publication of the Notice of Funding Opportunity (NOFO) in 2025. For further inquiries, interested applicants can contact Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275.
    GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for the establishment of the GREGoRi Data Coordination and Outreach Center, aimed at advancing the Genomics Research to Elucidate the Genetics of Rare Disease (GREGoR) program. This initiative seeks to enhance the diagnosis of rare genetic disorders by developing innovative tools and analytical methods to identify causal genes and variants, with the center serving as the primary coordination hub for data and resources generated by the GREGoRi program. The total estimated funding for this cooperative agreement is $2 million, with one award anticipated, and applications are expected to be due in 2026 following the publication of the Notice of Funding Opportunity (NOFO) in 2025. For further inquiries, interested applicants can contact Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275.
    Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Genomic Variant Interactions With Other Variants Or The Environment," aimed at studying the effects of genetic and environmental interactions on genomic variant impact. This initiative seeks to establish research frameworks that will experimentally test combinations of variants to identify significant interactions that could enhance the understanding of Genome-wide Association Studies (GWAS) and improve polygenic scores. The total estimated funding for this program is $10 million, with approximately five awards expected to be made. Interested applicants, including small businesses and eligible foreign entities, should prepare for the anticipated Notice of Funding Opportunity (NOFO) publication in 2025, with applications due later that year. For further inquiries, contact Mike Pazin at michael.pazin@nih.gov or by phone at 301-480-2629.
    Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders" (PAR-25-327), aimed at supporting Investigational New Drug (IND)-enabling studies and preparations for First-in-Human (FIH) clinical trials. This initiative focuses on advancing innovative gene-based therapies, such as oligonucleotides and viral vector approaches, for ultra-rare disorders affecting fewer than 6,000 patients, with an emphasis on projects that demonstrate robust proof of concept data and readiness for clinical trials. Eligible applicants include a wide range of organizations, including higher education institutions and various nonprofit and for-profit entities, with applications requiring detailed project planning and compliance with Good Manufacturing Practices (GMP). The application period opens on January 9, 2025, with a close date of October 8, 2027, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is set to announce a funding opportunity for the Genome Sequencing Center as part of the Gabriella Miller Kids First Pediatric Research Program, aimed at advancing research into childhood cancer and congenital anomalies. This initiative will support the addition of data to existing resources, enhance data types as technologies evolve, and incorporate clinic-based data sources to better understand the genetic pathways of these disorders. With an estimated total program funding of $6.6 million, this cooperative agreement does not require cost sharing and is open to small businesses. Interested applicants are encouraged to prepare for the upcoming Notice of Funding Opportunity (NOFO), with an estimated synopsis posting date of July 30, 2025, and a closing date of October 30, 2025. For further inquiries, potential applicants can contact Dr. Concepcion R. Nierras at 301-435-5840 or via email at concepcion.nierras@nih.gov.
    Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the establishment and continuation of Genomic Curation Expert Panels under the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The objective of this funding opportunity is to solicit applications from small businesses to manually curate, review, and define the clinical relevance of genes and variants, addressing the challenge of genomic variants with unknown significance that hinder advancements in genomic and precision medicine. This initiative is crucial for enhancing the understanding of the links between genes, variants, and diseases, ultimately contributing to a centralized public resource for expert-curated genetic data. The estimated total program funding is $880,000, with four expected awards, and interested applicants can contact Dr. Julia Jiaqi O'Reilly at Jiaqi.OReilly@nih.gov or 240-328-8649 for further information. Key deadlines include an estimated synopsis post date of March 25, 2026, and a close date of May 25, 2026, with awards anticipated by April 1, 2027.
    Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype," aimed at small businesses. This initiative seeks to support research that characterizes genomic variation and assesses the impact of individual variants on genome function through high-throughput methods, data collection on molecular and cellular phenotypes, and the development of robust data processing pipelines. The initiative is part of the Impact of Genomic Variation on Function (IGVF) Consortium, which will facilitate collaboration among funded centers to ensure resource accessibility and shared analysis strategies. The estimated total program funding is $3 million, with five awards expected, and the application process is anticipated to open in 2025, with a due date later that year. For further inquiries, interested applicants can contact Dr. Stephanie A. Morris at morriss2@mail.nih.gov or by phone at 301-435-5738.
    Notice of Intent to Publish a Notice of Funding Opportunity (NOFO) for the Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN)
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the Rare Diseases Clinical Research Consortia (RDCRC) as part of the Rare Diseases Clinical Research Network (RDCRN). This initiative aims to solicit applications for collaborative, multi-site research focused on advancing the diagnosis, management, and treatment of rare diseases, with an emphasis on addressing unmet clinical trial readiness needs. The funding, estimated at $1 million, will support specialized centers through cooperative agreements, with the NOFO expected to be published in winter 2024 and applications due in summer 2024. Interested applicants should prepare to develop meaningful collaborations, as the estimated award date is set for July 1, 2025.
    Notice of Intent to Publish a Funding Opportunity Announcement for Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for the "Supporting Talented Early Career Researchers in Genomics" program, utilizing the R01 activity code. This initiative aims to provide financial support to early career researchers in the field of genomics, facilitating the development of innovative projects that contribute to the understanding of human genetics. The estimated total program funding is $2 million, with an award ceiling of $400,000 per project, and the application period is expected to open on December 18, 2024, with a closing date of February 28, 2025. Interested applicants should prepare their proposals in advance, as the estimated award date is set for December 31, 2025.
    Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)" aimed at supporting innovative research in computational genomics and data science. This initiative encourages applications that focus on developing novel analytical methodologies, tools, and software that can be broadly applied to enhance human health and disease understanding, with an emphasis on scalable systems for managing complex genomic data. Eligible applicants include a wide range of organizations such as higher education institutions, nonprofits, and tribal colleges, with a maximum budget of $500,000 per year available for projects lasting up to five years. The application submission period opens on January 6, 2025, and closes on September 7, 2027. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.