Phased Multi-Site Clinical Trial: Testing Prevention of Cardiovascular Disease in Young Adults With High Lifetime Risk Using Surrogate Outcomes - Data Coordinating Center (Collaborative U24 Trial Required)
ID: 355311Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/355311

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-25-007.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity for a phased multi-site clinical trial aimed at preventing cardiovascular disease in young adults with high lifetime risk, specifically targeting men under 50 and women over 50. The initiative requires the development of a Data Coordinating Center (DCC) to provide project coordination, administration, data management, and biostatistical support for the trial, which will test interventions to reduce the progression of coronary atherosclerosis. This comprehensive effort, with approximately $8 million in total funding available over multiple years, aims to address significant knowledge gaps in early treatment of cardiovascular risks and improve health outcomes for young adults. Interested applicants must submit their proposals by October 28, 2024, and are encouraged to contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-HL-25-007-Full-Announcement.html
    RFA-HL-25-007.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), is offering a funding opportunity for a phased multi-site clinical trial aimed at preventing cardiovascular disease in young adults at high lifetime risk. The initiative focuses on a population with a low 10-year risk of cardiovascular events but a high lifetime risk, defined as men under 50 and women over 50. The trial will test interventions to reduce the progression of coronary atherosclerosis, utilizing a two-component primary prevention model: screening eligible participants and assessing the efficacy of pharmacological and behavioral interventions. The opportunities include developing a Data Coordinating Center (DCC) that will facilitate project coordination, administration, data management, and statistical support essential for the trial's success. Applicants must submit a collaborative proposal with a Clinical Coordinating Center (CCC) application by specified deadlines, and adherence to a Plan for Enhancing Diverse Perspectives (PEDP) is mandatory to promote inclusivity and engagement. The total funds available for the project over multiple years amount to approximately $8 million, with direct application budgets capped for each fiscal year. This comprehensive initiative aims to close significant knowledge gaps in early treatment of cardiovascular risks, potentially leading to changes in clinical practices and improved health outcomes for young adults.
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