The United States Agency for International Development (USAID) is inviting applications for the New Partners Initiative Translational HIV Research for Innovative Vaccines Ecosystem (NPI THRIVE), aimed at accelerating the development of a safe and effective HIV vaccine through collaborative research led by African scientists and institutions. This funding opportunity includes at least two cooperative agreements, with a total funding ceiling of $98.5 million over five years, structured around two main objectives: enhancing African-led clinical research and advancing promising immunogens towards first-in-human studies. The program emphasizes innovative, locally-led approaches and is open to a wide range of eligible applicants, including nonprofits without 501(c)(3) status, with a focus on projects predominantly within African countries to leverage local capabilities in addressing global HIV vaccine research challenges. Interested parties must submit a concept paper by January 28, 2025, and can contact Elton Fortson at npithrive@usaid.gov for further information regarding the application process.