The United States Agency for International Development (USAID) has issued a Request for Information (RFI) aimed at enhancing national health information systems and digital health ecosystems in partner countries. This RFI seeks insights from all organizations, particularly small businesses, to inform potential program designs that improve the quality and use of health data to meet public health objectives. The initiative emphasizes the importance of harmonizing health systems, strengthening local capabilities, and addressing barriers to effective data utilization, reflecting USAID's commitment to advancing global health through collaborative stakeholder engagement. Interested parties must submit their responses by March 22, 2024, and can direct inquiries to Imran Mahmud at imahmud@usaid.gov.