The United States Agency for International Development (USAID) has issued a Request for Information (RFI) for the Integrated Health Systems Strengthening Activity (IHSS), identified as RFI #2. This RFI aims to gather insights and feedback from interested parties regarding the anticipated activities to enhance planning and design for sustainable and equitable health systems across potentially 30 countries, with a funding ceiling between $300 million and $499.9 million. The IHSS program focuses on locally-led, evidence-driven approaches to promote universal health coverage and improve health outcomes, particularly in light of lessons learned from the COVID-19 pandemic. Interested parties are encouraged to submit their responses electronically by February 28, 2024, and can direct inquiries to Imran Mahmud at imahmud@usaid.gov or by phone at 202-567-4646.